Latest research paper from OTI has published on Diabetes

Prof. Qi’s research team in OTI has published their latest research paper on Diabetes, with the title of “Immunosuppressive effect of compound K on islet transplantation in a STZ-induced diabetic mouse model”.

According to statistics of the International Diabetes Federation, the world has 382 million people suffering from diabetes by 2013. Population suffers from diabetes in China has reached to 98 million. Islet transplantation is the most effective and promising method in the treatment of type 1 diabetes mellitus, but its long-term efficacy is limited by the islet graft survival time. Many factors affect the survival of islets, especially the toxic side effects caused by the immune suppressant after the implantation. Thus, finding less toxic immune suppressant will be the key solution to extend the graft survival time.

Compound (CPD) k is an extract from Radix Isatidis (Isatis tinctoria L.), it is a compound with highly unsaturated fatty acid. Based on the previous data, CPD K, as a leading synthetic analogues, is highly likely to be a potential immunosuppressive drug used in organ/tissue transplantation. The authors studied the effect of CPD K application in diabetic mice, and found that the survival time of islet allograft was significantly prolonged after 10 days of treatment. Studies have also found that CPD K has a synergistic effect with rapamycin. Such suppressive effect was shown in the inhibition on the activation and proliferation of T cells, inducing regulatory T cells and blocking the NF- NF B signaling pathway. All of the results showed that K Cpd was highly likely to be a potential immunosuppressive drug used in islet transplantation.

This project was supported by National Ministry of science and Technology and National Natural Science Foundation of China.

(7th July 2014)