OTI has made a progress in understanding the diabetic influenced reproduce system mechanism

With the increasing number of diabetic patients; infertility, miscarriage, and defects in fetus are becoming more and more prominent in female patients. Researchers are investigating possible mechanisms through different studies, from the aspects of egg formation, embryo development, and embryo implantation and so on. A graduate student Yu Liu, from OTI reproductive team, found that the accumulation of sugar metabolic intermediates (acetone aldehyde) in diabetic patients overly produces free radicals, which would damage the oocytes. Subsequently, Liu used a natural antioxidant, resveratrol, to verify his hypothesis. The addition of resveratrol is able to diminish the free radical induced damage in oocyte, particularly indicating the positive correlation between the level of free radicals with oocytes’ growth retardation, DNA damage and mitochondrial function abnormalities. This study may lead to a new perception in treating the fertility issue occurred in diabetic women. The results of this study are published in PLOS ONE.

Healthy egg is a necessary factor to determine the fertility of women. The research group located in The Institute of Life Science of Zhejiang University, Hengyu Fan and his team demonstrated that CRL4 protein complex is strongly associated with the activity of egg. This finding revealed the molecular mechanism in improving female fertility, delaying the menopausal occurrence and provided new insights into the understanding of premature ovarian failure and other female infertility disease etiology.

(23rd November 2013)